Nadal J, Deverdun J, de Champfleur NM, et al. - Researchers intended to determine if there is an association between cerebral blood flow (CBF), retinal vascular fractal dimension (FD) and other retinal vascular markers using linear regression models adjusted for age and gender. Cross-sectional analysis including 26 people ≥ 65 years old from the Cognitive REServe and Clinical ENDOphenotype cohort of relative healthy older adults. By using the semi-automated Singapore Eye Vessel Assessment (SIVA) software, retinal vascular FD was measured from fundus photographs. Using a 2D pulsed ASL MRI sequence, CBF was estimated. According to this pilot study, retinal venular complexity summarized by the FD was linked to CBF as well as retinal arteriolar tortuosity and branching angle. No association between Global CBF and other SIVA parameters was found. For confirmation of these results, larger prospective clinical studies are required.