Pfau M, et al. - Researchers conducted this retrospective, monocentre cohort study to assess the applicability of mesopic light sensitivity measurements obtained by fundus-controlled perimetry (FCP, also termed ‘microperimetry’) as clinical trial endpoint in Stargardt disease (STGD1). For this investigation, 271 eyes of 136 patients (age, 37.1 years) with STGD1 and 87 eyes of 54 healthy controls (age, 41.0 years) had mesopic FCP, using a pattern of 50 stimuli (achromatic, 400–800 nm) centred on the fovea. Findings suggested that the sensitivity of mesopic light measured via FCP is accurate and susceptible to functional changes. It represents a possible clinical result both for natural history studies and for prospective interventional studies in STGD1 patients.