Tantawy AA, et al. - This study assessed the value of reticulocyte hemoglobin content (Ret He) as a marker of iron availability for erythropoiesis in childhood cancer and the effect of oral iron supplementation on hematologic parameters in patients with low Ret He. Researchers conducted a prospective study including a total of 100 pediatric individuals with cancer on chemotherapy who were screened for the presence of anemia. They categorized individuals according to their level of Ret He into normal or low Ret He applying a cutoff level of 28 pg. The outcomes of this study indicate that Ret He could be applied as an easy and affordable tool for the evaluation of iron deficiency anemia in childhood cancer during chemotherapy treatment. The results suggests that a trial of oral iron in individuals with low Ret He may be beneficial to correct the correlated anemia.