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Resting heartbeat complexity predicts all‐cause and cardiorespiratory mortality in middle‐ to older‐aged adults from the UK Biobank

Journal of the American Heart Association Jan 24, 2021

Gao L, Gaba A, Cui L, et al. - A large population cohort was used to investigate whether decreased distribution entropy (DistEn; a recently introduced complexity measure meant specifically for shorter duration heartbeat recordings) predicted increased mortality. Researchers assessed prognostic worth of DistEn among 7,631 middle‐older–aged UK Biobank participants who underwent 2‐minute resting ECGs (mean age, 59.5 years; 60.4% women). The risk rose by 36%, 56%, and 73% for all‐cause, cardiovascular, and respiratory disease–related mortality, respectively, in relation to each 1‐SD decrease in DistEn, as revealed in Cox proportional hazards models with adjustment for demographics, lifestyle factors, physical activity, cardiovascular risks, and comorbidities. In this study, resting heartbeat complexity from short, resting ECGs was found to be independently related to mortality among middle‐ to older‐aged adults. These risks seemed most prominent in middle‐aged participants with prior myocardial infarction, and may have a unique contribution to death risk screening.

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