Auwal SM, et al. - Using central composite design (CCD) by response surface methodology (RSM), the authors aimed to optimise the conditions for the hydrolysis of stone fish protein to produce antioxidant hydrolysates. To optimise the production of stone fish protein hydrolysates containing antioxidant peptides, RSM could be considered as a promising strategy. The authors believed that this finding would enhance the potential of stone fish protein hydrolysates (SHs) as a therapeutic bioactive ingredient in functional foods development.