Kocak B, et al. - In this retrospective study involving 30 subjects with clear cell renal cell carcinoma from a public database, researchers studied the potential impact of manual segmentation variability intra- and interobserver on the reliability of single-slice–based 2D CT texture analysis of renal masses. For reliability analysis, the intraclass correlation coefficient was used. The rates of features with good to excellent reliability in the intraobserver analysis were 84.4–92.2% for unenhanced CT and 85.5–93.1% for CECT. The auhors concluded that single-slice–based 2D CT texture analysis of renal masses is sensitive to variability in intra- and interobserver manual segmentation. Therefore, unless a reliability analysis is considered in the workflow, it may lead to unreproducible results in radiomic analysis.