Niiranen TJ, et al. - In 2,119 Framingham Offspring Cohort participants (mean age, 60 years; 57% women), researchers assessed the prevalence and prognostic significance of mismatch between pulse pressure and arterial stiffness. They measured carotid-femoral pulse wave velocity (CFPWV) and central pulse pressure (CPP) of participants, who were classified into four groups according to CPP and CFPWV status (characterized as high/low based on ≥age- and sex-specific median values) and followed up for cardiovascular disease (CVD) events. They found inconsistent CPP and CFPWV status at baseline in 832 of 2,119 (39%) participants, 417 with low CPP and high CFPWV, and 415 with high CPP and low CFPWV. Findings revealed a common prevalence of pulse pressure-arterial stiffness mismatch in the community. The multivariable-adjusted risk for CVD events in individuals with a CPP-CFPWV mismatch was similar with that seen in the low CPP with low CFPWV (referent group), while those with a high CPP with high CFPWV experienced significantly increased CVD risk.