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Relationship between proximity of choriocapillaris flow deficits and enlargement rate of geographic atrophy

Graefe's Archive for Clinical and Experimental Ophthalmology Feb 16, 2020

Alagorie AR, Nassisi M, Verma A, et al. - In this retrospective study involving 22 patients (30 eyes), researchers sought to compare choriocapillaris (CC) flow deficits (FD) in eyes with geographic atrophy (GA) at different distances from the border of the GA lesion with yearly enlargement rate (yER) of GA. From individuals with GA who were imaged at Doheny Eye Centers between 2016 and 2018, spectral domain optical coherence tomography (SD-OCT) and SD optical coherence tomography angiography (OCTA) images were obtained. Data reported that the mean yER was 0.2 ± 0.15 mm. Findings suggested a significant association of FD% in the first five rings (from 0 to 500 μm from the border of GA) with the yER. However, no statistically significant link was found between the yER and CC FD% beyond 500 μm from the GA lesion. Only the choriocapillaris FD% tends to predict the rate of enlargement of these lesions in the 500-μm area immediately surrounding GA lesions.
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