Perreault L, et al. - Researchers investigated if regression to normal glucose regulation (NGR) also decreased the risk for microvascular disease (MVD). Regression to NGR was correlated with a lower prevalence of aggregate MVD in models adjusted for age, sex, race/ethnicity, baseline A1C, and treatment arm. In models that involved average A1C during follow-up or diabetes status at the end of follow-up, this relationship was lost. In assessing the relationship between regression to NGR and prevalence of nephropathy and retinopathy, individually, comparable outcomes were seen. Across the A1C range, risk for aggregate MVD, nephropathy, and retinopathy increased. Regression to NGR correlated with a reduced prevalence of aggregate MVD, nephropathy, and retinopathy, principally due to lower glycemic exposure over time. Moreover, the differential risk for the MVD subtypes started in the prediabetes A1C range.