• Profile
Close

Reduction in glycated hemoglobin and daily insulin dose alongside circadian clock upregulation in patients with type 2 diabetes consuming a three-meal diet: A randomized clinical trial

Diabetes Care Oct 03, 2019

Jakubowicz D, Landau Z, Tsameret S, et al. - In this randomized clinical trial involving 28 volunteers with diabetes (BMI 32.4 ± 5.2 kg/m2 and HbA1c 8.1 ± 1.1% [64.5 ± 11.9 mmol/mol]), researchers ascertained if a three-meal diet (3Mdiet) with a carbohydrate-rich breakfast could upregulate the expression of the clock gene and thus allow insulin dose reduction, leading to weight loss and better glycemic control vs an isocaloric six-meal diet (6Mdiet). Study participants were randomly assigned to 3Mdiet or 6Mdiet. Unlike an isocaloric 6Mdiet, a 3Mdiet results in weight loss, a significant reduction in HbA1c, appetite, and overall glycemia, with a reduction in daily insulin. Upregulation of clock genes seen in this diet intervention could help improve the metabolism of glucose. On the 3Mdiet, clock genes displayed oscillation, increased expression, and higher amplitude compared with the 6Mdiet.
Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay