Ling C, Zhang Z, Wu Y, et al. - Experts aspired to explore if altered venous oxygen saturation was associated with clinical phenotypes of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) patients. They compared venous susceptibility of cortical veins between 41 CADASIL patients and 43 age- and gender-matched healthy controls using 7.0-T susceptibility weighted imaging and mapping. Investigators found that venous susceptibility in patients with CADASIL increased with age and was higher than in healthy controls. A positive association was found between venous susceptibility and the age-related white matter change scores, number of lacunar infarctions, the number of cerebral microbleeds, and small-vessel disease scores in CADASIL patients. Furthermore, increased venous susceptibility was linked to higher modified Rankin Scale scores in patients with CADASIL after adjustment for the age- and small-vessel disease scores. The results show that extensive cerebral hypoperfusion can cause central nervous system impairment in CADASIL, and susceptibility weighted imaging and mapping may be clinically used to assess CADASIL patients' condition.