Austin ED, Sullivan SS, Macesic N, et al. - Researchers sought to understand the changing epidemiology of Staphylococcus aureus bacteremia, as well as the variables associated with poor outcomes, in order to attain insight into potential interventions. In this retrospective, observational cohort study, adult patients who had S. aureus bloodstream infections between January 1, 2007 and December 31, 2015 were assessed from an academic medical center in New York City. For trend analysis, division of participants was done into 3 periods: group 1 (2007–2009), group 2 (2010–2012), and group 3 (2013–2015). They identified 1,264 episodes of methicillin-susceptible S. aureus (MSSA) and 875 episodes of methicillin-resistant S. aureus bacteremia; a rising proportion was observed due to MSSA (55% group 1; 59% group 2; 63% group 3). A decline in mortality in MSSA bloodstream infection was noted, which is linked with a reduction in time to targeted therapy. Outcomes thereby underscore the potential for rapid diagnostics and early optimization of therapy to influence consequences in MSSA bacteremia.