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Reduced corneal nerve fibre length in prediabetes and type 2 diabetes: The Maastricht Study

Acta Ophthalmologica Feb 08, 2020

De Clerck EEB, Schouten JSAG, Berendschot TTJM, et al. - Using multivariable linear regression, researchers desired to know to what extent a decrease in corneal nerve fibre length (CNFL) is present in people with prediabetes or type 2 diabetes (DM2) vs people with normal glucose metabolism (NGM). For this analysis, they evaluated total CNFL per mm2 in the subbasal nerve plexus of the cornea in 134 candidates (mean age 59 ± 8 years, 49% men, 87 NGM, 20 prediabetes, 27 DM2) utilizing composite images acquired by corneal confocal microscopy. In people with DM2 vs people with NGM, a significant reduction in CNFL was observed. A pattern of reduction in CNFL between people with NGM and prediabetes has been reported. Reducing the length of corneal nerve fibre may lead to a delayed healing of the cornea and an increased risk of corneal complications following surgery.
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