Virostko J, et al. - Researchers retrospectively studied National Cancer Data Base data from 2004 to 2015 to appraise changes in the proportion of cases diagnosed at an age younger than 50 years using the Cochran-Armitage test for trend. This study yielded data of 130,165 patients diagnosed at an age younger than 50 years and data of 1,055,598 patients diagnosed at the age of 50 years or older. The analysis revealed a continued increase in the proportion of persons diagnosed with colorectal cancer (CRC) at an age younger than 50 years in the United States over the past decade. Presentation at more advanced disease was reported in younger adults. Among men, only non-Hispanic whites had an increase in diagnosis at ages younger than 50 years, whereas, among women, increases in younger diagnoses overtime was reported in Hispanic and non-Hispanic whites. Urban areas but not rural areas showed a rise in the proportion of younger-onset CRC cases.