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Reassessing the role of antitachycardia pacing in fast ventricular arrhythmias in primary prevention implantable cardioverter defibrillator recipients: Results from MADIT-RIT

Heart Rhythm Dec 02, 2020

Schuger C, Daubert JP, Zareba W, et al. - Given that the risk of inappropriate ICD interventions was attenuated by high rate cut-off (Arm B) and delayed therapy (Arm C) vs conventional programming (Arm A) in MADIT-RIT, however, appropriate but unnecessary therapies were not assessed, and therefore, researchers herein determined the value of ATP for fast ventricular arrhythmias (VA) ≥ 200 bpm in primary prevention (PP) ICD patients. In MADIT-RIT patients managed for VA ≥ 200 bpm, comparisons were performed between ATP only, ATP and shock, and shock only rates. Between these randomized groups, the only disparity was the time delay between VT identification and treatment (3.4 sec vs 4.9 sec vs 14.4 sec). Findings revealed a significant decrease in ATP interventions, in MADIT-RIT, with therapy delays because of spontaneous termination, and there was no difference in shock therapies, this indicates that earlier interventions for VA ≥ 200 bpm are possibly avoidable resulting in an overestimation of the worth of ATP in PP ICD recipients.

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