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Rate or rhythm control in older atrial fibrillation patients: Risk of fall-related injuries and syncope

Journal of the American Geriatrics Society Oct 25, 2019

Dalgaard F, Pallisgaard JL, Numé AK, et al. - Researchers examined how rate and/or rhythm control may influence fall-related injuries and syncope in a real-world older atrial fibrillation (AF) cohort. They performed a retrospective cohort study of 100,935 patients (median age: 78 years) with AF aged 65 years or older claiming prescription of rate-lowering drugs and/or anti-arrhythmic drugs (AADs). The use of rate-lowering monotherapy was compared with rate-lowering dual therapy, AAD monotherapy, and AAD combined with rate-lowering therapy. In AF patients aged 65 years and older, a higher risk of fall-related injuries and syncope was observed in correlation to AAD use; those treated with AADs exhibited the highest risk within the first 14 days. A higher risk was observed only in correlation with amiodarone use.
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