Castle JR, et al. - Researchers ascertained if a dual-hormone closed-loop system using wearable sensors to detect exercise and adjust dosing to reduce exercise-related hypoglycemia would outperform other forms of closed-loop and open-loop therapy. Participants underwent four arms in randomized order: dual-hormone, single-hormone, predictive low glucose suspend, and continuation of current care over 4 outpatient days. Outcomes revealed a reduction in hypoglycemia in physically active adults with type 1 diabetes with the addition of glucagon delivery to a closed-loop system with automated exercise detection reduces.