Saito YA, et al. - Researchers conducted a double-blind, placebo-controlled trial to test the effectiveness of pregabalin on gastrointestinal symptoms in irritable bowel syndrome (IBS). For this investigation, they randomized adults meeting IBS Rome III criteria with ≥3 pain attacks per month to pregabalin 225 mg vs placebo twice daily for 12 weeks. Using a chi-squared test, adequate relief and change in pain score were evaluated. In this analysis, 85 patients were recruited and randomized. The study findings suggested that pregabalin could be beneficial for IBS abdominal pain, bloating and diarrhea.