Bär S, Kavaliauskaite R, Ueki Y, et al. - In this retrospective post hoc study, researchers sought to determine the incremental value of quantitative flow ratio (QFR, a novel, noninvasive, vasodilator‐free tool to evaluate the hemodynamic significance of coronary stenoses) over angiography in nonculprit lesions among patients with ST‐segment–elevation myocardial infarction receiving angiography‐guided complete revascularization. The primary endpoint comprised cardiac death, spontaneous nontarget vessel myocardial infarction, and clinically indicated nontarget vessel revascularization (ie, ≥ 70% diameter stenosis [DS] via 2‐dimensional quantitative coronary angiography or ≥ 50% DS and ischemia) at 5 years. It was found at 5 years that patients with QFR ≤ 0.80 had a significantly higher rate of the primary endpoint, vs those with QFR > 0.80, driven by higher rates of nontarget vessel myocardial infarction and nontarget vessel revascularization with no significant disparities for cardiac death. Overall, findings indicate that QFR has an incremental value over angiography‐guided percutaneous coronary intervention for nonculprit lesions in ST‐segment–elevation myocardial infarction patients receiving primary percutaneous coronary intervention.