Corvi F, Cozzi M, Corradetti G, et al. - In this cross-sectional, retrospective, multicenter, observational study, researchers examined choriocapillaris flow deficits (CC FD) in a group of eyes with Type 3 macular neovascularization (MNV) vs a group of eyes with Type 1 and/or 2 MNV vs healthy eyes. Consecutive patients with Type 3 MNV, Type 1 and/or 2 MNV, and age-matched controls were involved. Twenty Type 3, 20 Type 1 and/or 2 MNV [13 (65%) Type 1 MNV, 1 (5%) Type 2 MNV, and 6 (30%) mixed Type 1 and 2 MNV], and 20 age-matched controls were involved. No significant differences between Type 1/2 MNV and controls were noted. Compared with eyes with Type 1/2 MNV and normal control eyes, CC FD was significantly greater in the peripheral macular regions of eyes with Type 3 MNV. In eyes with various MNV subtypes, pathogenic choroidal mechanisms can differ. Whereas the development of Type 1/2 MNV may be driven by focal CC impairment, diffuse CC disruption may be more significant in Type 3 MNV eyes.