Yu G, Aaberg MT, Patel TP, et al. - Researchers conducted this retrospective case series to identify demographic risk factors and markers of advanced diabetic retinopathy (DR) that are correlated with increased areas of nonperfusion (NP) and neovascularization (NV) in eyes with disease ranging from no DR but diagnosed as having diabetes to proliferative DR (PDR) and to calculate a threshold total area of NP that may be related to an increased risk of PDR. In total, 363 candidates (651 eyes), mean (SD) age was 59.4 (13.7) years, diagnosed as having type 1 or 2 diabetes receiving ultrawidefield fluorescein angiography (UWF FA) were involved. The results indicate that NP and NV can be quantified by UWF FA. Such interpreted biomarkers with demographic risk factors may help predict the course of the disease. Conclusions are limited by determination and bias in information, as the results are from retrospective data.