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Pulmonary nodular and cystic light chain deposition disease: A retrospective review of 10 cases

Respiratory Medicine Mar 25, 2020

Baqir M, et al. - Researchers describe clinical as well as radiologic findings of pulmonary light chain deposition disease (LCDD). They analyzed 10 cases with biopsy-confirmed pulmonary LCDD seen at Mayo Clinic. The median age at diagnosis was 55 years (range, 39–77 years). Eight patients were women and 7 were never-smokers. The most common respiratory symptoms were dyspnea (n = 3) and chest pain (n = 3). Sjögren syndrome (n = 6), sarcoidosis (n = 1), and limited scleroderma (n = 1) were identified as associated conditions. Mucosa-associated lymphoid tissue (MALT) lymphoma was detected in 8 patients. A median follow-up of 2.3 years (range, 0.5–9.9 years) revealed the deaths of 2 patients. Overall, cysts and nodules characterized pulmonary LCDD. The disease was found to be related to MALT lymphoma, particularly in the setting of Sjögren syndrome.

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