Scharfenberg E, et al. - Researchers determined if an increased risk of extraocular comorbidities is present in patients with pseudoexfoliation syndrome (PEX) in this large, retrospective case-control analysis including cases and controls identified from consecutive patients over 50 years of age undergoing in-house ophthalmological surgeries under general anaesthesia or in standby preparedness for general anaesthesia. Depending on PEX status, the participants were categorized as those with PEX-positive (n = 325) or PEX-negative (n = 911) status. An increased risk of respiratory, cardiovascular, and urogenital comorbidities was confirmed in PEX-positive patients, as well as an increased risk of cardiac valve disorders and benign prostate hyperplasia was observed in these patients, which appeared possible manifestations of the underlying systemic elastotic fibrillopathy.