Moss JL, et al. - Given that the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database currently offers county-level information on rurality for cancer patients in its catchment area, researchers sought for more nuanced measures of rurality to improve etiologic and surveillance studies. Using U.S. Department of Agriculture's Rural Urban Commuting Area (RUCA) codes and U.S. Census data on percent of the people living in non-urban regions, a sample utility analysis of census tract-level measures of rurality was performed and disclosure risk was analyzed. Quite low disclosure risk was reported: <0.03% of census tracts and <0.03% of cancer cases were uniquely recognized. In utility analyses, an SES gradient was shown in lung and breast cancer incidence and survival; relatively similar patterns were observed across rurality variables. To a specialized SEER 18 database, RUCA and Census rurality measures were added. For future interventions to enhance cancer prevention and control, such investigations can offer critical research support.