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Progressive chronic retinal axonal loss following acute methanol-induced optic neuropathy: Four-year prospective cohort study

American Journal of Ophthalmology May 02, 2018

Nurieva O, et al. - Researchers sought to study the dynamics and clinical determinants of chronic retinal nerve fibre layer thickness (RNFL) loss after methanol-induced optic neuropathy. Findings suggested that during the following years, methanol-induced optic neuropathy could lead to chronic retinal axonal loss. The strongest predictor of chronic RNFL thickness decrease was arterial blood pH on admission. Experts noted an association of chronic retinal neurodegeneration with the progressive loss of visual functions and necrotic brain lesions. In 31% survivors of methanol poisoning, abnormal RNFL thickness was registered and chronic axonal loss in 24% patients.
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