Webb AJS - Given hypertension-related cardiovascular events are especially related to raised systolic blood pressure (SBP) in late life, yet there is no clarity regarding long-term interactions between SBP, diastolic BP (DBP) and arterial stiffness in development of late-life hypertensive phenotypes, and therefore, the researcher examined links between arterial stiffness index (ASI), SBP, DBP, and their progression, and transition from normotension (< 140/90 mm Hg) to hypertension or elevated ASI (> 10 m/s) in the UK Biobank. Findings revealed midlife DBP as the strongest predictor of progression of arterial stiffness, while a link was identified between arterial stiffness and earlier transition to a falling DBP. More intensive control of midlife DBP may be needed to prevent long-term harms related to arterial stiffness.