Prognostic value of serial high-sensitivity troponin T measurements in adults with congenital heart disease
Canadian Journal of Cardiology Dec 18, 2019
Geenen LW, Baggen VJM, van den Bosch AE, et al. - Researchers investigated the prognostic value of serial high-sensitivity troponin T (hs-TnT) measurements in stable adults with congenital heart disease (ACHD) patients. They performed blood sampling at enrollment and thereafter yearly during scheduled visits, up to 4 years to assess Hs-TnT, NT-proBNP and eGFR measures in this prospective study (2011-2013) of 602 consecutive ACHD patients. The analysis revealed an increase in hs-TnT levels in stable ACHD patients before the occurrence of an event, and an association was observed between repeated hs-TnT and the risk of adverse cardiac events. A two-fold higher hs-TnT was associated with all-cause mortality, heart failure, arrhythmia, hospitalization, cardiac (re)interventions or thromboembolic events. However, repeated hs-TnT vs repeated NT-proBNP was not superior.
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