Abou R, Goedemans L, Montero-Cabezas JM, et al. - Researchers investigated the relationship between multilayer left ventricular (LV) global longitudinal strain (GLS) and prognosis in patients suffering from mildly reduced or preserved LV ejection fraction (EF) following ST-segment myocardial infarction (STEMI). A retrospective analysis of patients with first STEMI and LVEF>45% was conducted. Using 2-dimensional speckle tracking echocardiography, baseline multilayer (endocardial, mid-myocardial and epicardial) LV GLS were recorded. All-cause mortality was assessed during follow-up. This analysis involved 569 patients (77% male, 60 ± 11 years). Findings demonstrated an independent connection of both ageing and reduced LV GLS of the epicardium (reflecting transmural scar formation) with all-cause mortality, post-adjustment for clinical and echocardiographic variables, in these contemporary STEMI patients with mildly reduced or preserved LVEF.