Prognostic value of late gadolinium enhancement for the prediction of cardiovascular outcomes in dilated cardiomyopathy
Circulation: Cardiovascular Imaging Apr 24, 2020
Alba AC, Gaztañaga J, Foroutan F, et al. - Researchers performed a retrospective examination of links between the presence of late gadolinium enhancement (LGE) and adverse cardiovascular events among patients suffering from dilated cardiomyopathy in a multicenter setting as part of an emerging global consortium (MINICOR [Multi-Modal International Cardiovascular Outcomes Registry]). Participants were consecutive patients having dilated cardiomyopathy who were referred for cardiac magnetic resonance (2000–2017) at 12 institutions in 4 countries. The composite primary endpoint was all-cause death, heart transplantation, or left ventricular assist device implant, and the secondary arrhythmic endpoint of sudden cardiac death or appropriate implantable cardioverter-defibrillator shock was also assessed. The link of LGE with 1.5-fold risk of the primary endpoint and 1.8-fold risk of the arrhythmic endpoint was revealed in multivariable analyses. Patients with multiple LGE patterns were shown to have increased primary endpoint risk, and those receiving primary prevention implantable cardioverter-defibrillator and widening QRS had a higher arrhythmic risk. Findings of this large multinational investigation revealed that the presence of LGE displayed strong prognostic value for detection of high-risk patients.
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