Nicol M, Deney A, Lairez O, et al. - In this multicentre analysis of patients with light chain or transthyretin cardiac amyloidosis (CA), researchers sought to determine how functional evaluation and risk stratification of patients with CA could be aided by cardiopulmonary exercise test (CPET). The occurrence of death or heart failure hospitalization was assessed as the primary prognostic endpoint. At multivariate Cox analysis, the factors that were related to the primary outcome were: peak VO₂ (peak oxygen consumption)  ≤13 mL/kg/min, circulatory power ≤ 1730 mmHg/mL/min and NT‐proBNP (N‐terminal pro B‐type natriuretic peptide) ≥ 1800 ng/L. In patients with both peak VO₂ >13 mL/kg/min and NT‐proBNP <1800 ng/L, there was no occurrence of events, while a very high‐risk subgroup was revealed by the link of VO₂ ≤13 mL/kg/min with NT‐proBNP ≥1800 ng/L. Experts concluded CPET to be useful in CA for evaluating functional capacity, circulatory and chronotropic responses and the prognosis of patients along with cardiac biomarkers.