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Prognostic value of cardio‐pulmonary exercise testing in cardiac amyloidosis

European Journal of Heart Failure Oct 12, 2020

Nicol M, Deney A, Lairez O, et al. - Researchers conducted this multicenter study to determine the usefulness of cardio‐pulmonary exercise test (CPET) in the functional evaluation as well as risk stratification of patients with cardiac amyloidosis (CA). Patients with light chain or transthyretin CA received exhaustive assessment including CPET and follow‐up. The occurrence of death or heart failure (HF) hospitalization was the primary prognostic endpoint. Overall 37 deaths and 44 HF hospitalizations were reported following a median observation of 20 months. In multivariate Cox analysis, a link with the primary outcome was demonstrated by peak VO2 ≤ 13 mL/kg/min, circulatory power ≤ 1800 mmHg.mL.min−1 and NT‐proBNP ≥1800 ng/L. Overall, experts suggested the usefulness of CPET in assisting the evaluation of functional capacity, circulatory and chronotropic responses in CA, as well as in aiding the assessment of prognosis of patients along with cardiac biomarkers.

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