Namikawa T, et al. - In 262 patients who received chemotherapy for unresectable advanced gastric cancer at Kochi Medical School from 2007 to 2015, researchers assessed the prognostic value of alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) together with host-related factors. For this investigation, they analyzed clinicopathological information and systemic inflammatory response data for associations between baseline cancer-related prognostic variables and survival outcomes. The median survival time of high ALP, high LDH, high total bilirubin, high aspartate aminotransferase, high alanine transaminase, high gamma-glutamyltransferase, high creatinine was significantly lower. In patients receiving chemotherapy for unresectable and recurrent gastric cancer, high level of ALP is an independent, worse prognosis factor.