Zhu B, et al. - Researchers investigated the prognostic value of interleukin (IL)-37 expression and neutrophil levels in colorectal cancer (CRC) via retrospectively analyzing IL-37 expression, CD66b⁺ neutrophil levels, and mismatch repair (MMR) status in 337 paraffin-embedded CRC specimens from the training cohort by immunohistochemistry. In addition, they formed nomograms using several risk factors to evaluate survival and assessed their performance with respect to calibration, discrimination, and clinical usefulness. Findings suggest that for CRC patients, intratumoral IL-37, CD66b⁺ neutrophils, and MMR status were the independent prognostic factors. Nomograms incorporating these biomarkers and clinicopathological features may conveniently assist in the individualized prediction of disease-free survival and overall survival.