Bellou V, et al. - Through a systematic review, experts mapped and evaluated prognostic models for outcome prognostication in individuals with COPD. The systematic search gave 228 suitable articles, representing the development of 408 prognostic models, the external validation of 38 models, and the validation of 20 prognostic models obtained for diseases other than COPD. The 408 prognostic models were formed in three clinical settings ie, outpatients (n = 239), individuals admitted to hospital (n = 155), and individuals attending the emergency department (n = 14). Among the 408 prognostic models, mortality (n = 209), the risk for acute exacerbation of COPD (n = 42), and risk for readmission following the index hospital admission (n = 36) were the most common endpoints. Overall, age (n = 166), forced expiratory volume in one second (n = 85), gender (n = 74), BMI (n = 66), and smoking (n = 65) were the most generally used predictors. A hundred models were internally approved and 91 investigated the calibration of the developed model. For 286 models a model presentation was not available, and only 56 models were proffered via the full equation. For 311 models, model discrimination using the C statistic was possible. Thirty-eight models were externally verified, although only in 12 of these was the validation done by a fully independent team. With an overall low risk of bias according to the Prediction model Risk Of Bias ASsessment Tool, just seven prognostic models were recognized. Thus, for outcome prediction in initials with COPD, the study yielded detailed mapping and evaluation of the prognostic models. The verdicts designated various methodological pitfalls in their development and a flat rate of external validation.