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Prognostic markers and long‐term outcomes after aortic valve replacement in patients with chronic aortic regurgitation

Journal of the American Heart Association Dec 12, 2020

Kim MS, Kim JH, Joo HC, et al. - Researchers assessed the echocardiographic prognostic factors related to improved left ventricular (LV) systolic function following aortic valve replacement, and also they compared the long‐term results post-aortic valve replacement in chronic aortic regurgitation (AR) patients with or without LV dysfunction. Participants were 280 patients who received aortic valve replacement due to chronic aortic regurgitation. A comparison was performed between patients with reduced LV systolic function (LV ejection fraction [LVEF] < 50%; group reduced LVEF [rEF]; N = 80) vs those with preserved LV systolic function (LVEF ≥ 50%; group preserved LVEF; N = 200). At postoperative 10 years, overall and cardiac mortality‐free survival rates were identified to be 80.1% and 92.9% in group rEF and 87.3% and 97.2% in group preserved LVEF, respectively. Overall, in patients with chronic aortic regurgitation, long‐term results and survival following aortic valve replacement were shown to be associated with preoperative LV function. There was a correlation of preoperative early diastolic transmitral flow velocity/mitral annular tissue velocity ratio with the postoperative improvement or normalization of LVEF as well as long‐term survival, specifically in group rEF patients.

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