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Prognostic implications of statin intolerance in stable coronary artery disease patients with different levels of high-sensitive troponin

BMC Cardiovascular Disorders Jul 19, 2019

Hai JJ, et al. - Given the uncertainity regarding the prognostic implication of statin in tolerance (SI) in those with stable coronary artery disease (CAD), researchers investigated their hypothesis of higher prognostic significance of SI in stable CAD patients with elevated high-sensitive cardiac troponin I (hs-cTnI). From the prospective Hong Kong CAD study, they studied a total of 952 stable CAD patients who had complete clinical data, biomarker measurements and who were prescribed statin therapy. Among these, 13 (1.4%) with complete SI and 125 (13.1%) with partial SI were identified. The analysis suggested an independent predictive value of SI for major adverse cardiovascular events in patients with stable CAD and high hs-cTnI, but not in those with low hs-cTnI. Hence stable CAD patients who have SI could be stratified for intensive lipid-lowering therapy using non-statin agents via measuring hs-cTnI.
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