Vemulapalli S, et al. - Via the Transcatheter Valve Therapy Registry from 2015 through 2017, 113,662 transcatheter aortic-valve replacement (TAVR) procedures conducted at 555 hospitals by 2,960 operators were assessed by experts to determine how procedural volume relates to outcomes for TAVR. Between the annualized volume of transfemoral TAVR procedures and mortality, a significant inverse correlation was ascertained. In comparison to the hospitals in the highest-volume quartile, adjusted 30-day mortality was greater and more variable at hospitals in the lowest-volume quartile. A relative decrease of 19.45% in adjusted mortality between a mean annualized volume of 27 and 143 procedures in the lowest-volume quartile and in the highest-volume quartile, respectively, was observed. For transfemoral TAVR procedures from 2015 through 2017, an inverse volume-mortality relationship was ascertained. At hospitals with a low procedural volume as compared to at hospitals with a high procedural volume, mortality at 30 days was greater and variable.