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Procalcitonin and n-terminal pro-B-type natriuretic peptide for prognosis in septic acute kidney injury patients receiving renal replacement therapy

Blood Purification Jul 20, 2019

Sheng X, et al. - The prognostic value of procalcitonin (PCT) and ­N-terminal pro-B-type natriuretic peptide (NT-proBNP) in septic acute kidney injury patients (AKI) patients who received renal replacement therapy (RRT) was investigated. In this retrospective study, 81 septic AKI patients were included and were tested for PCT and NT-proBNP at RRT initiation. Death was reported for 48 (59.3%) patients during hospitalization. Non-survivors vs survivors had a significantly higher median of NT-proBNP, while no significant differences in PCT were observed. As per Kaplan-Meier survival curve analysis, there is an association of increased NT-proBNP level with 28-day mortality however, on combining with PCT no statistical difference in 4 different level groups was noted. These findings indicate a certain predictive value of NT-proBNP for the prognosis in septic AKI patients who received RRT. The initial PCT value for prognosis seems inadequate.
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