Okosieme OE, et al. - According to the method and effectiveness of primary therapy in Graves' disease, routinely treated with antithyroid drugs, radioiodine, or surgery, researchers assessed cardiovascular morbidity and mortality in this retrospective cohort study. Patients with hyperthyroidism diagnosed between January 1, 1998 and December 31, 2013 were found via a thyroid-stimulating hormone (TSH)-receptor antibody (TRAb) test register in south Wales, UK; their clinical data was then imported into the All-Wales Secure Anonymised Information Linkage (SAIL) Databank (Swansea University, Swansea, UK). Early and efficacious control of hyperthyroidism results in improved survival vs less effective control among patients with Graves' disease, no matter the treatment method. In managing Graves ' disease, quick and continued control of hyperthyroidism should be the priority; patients unlikely to attain remission via antithyroid drugs alone should be offered early definitive treatment with radioiodine.