Azizi-Namini P, et al. - In ambulatory participants with heart failure (HF), researchers examined the prevalence of thiamin deficiency (TD) via this cross-sectional analysis. They also assessed the links between thiamin status and HF severity, dietary thiamin intake, diuretic use, and circulating neurohormones. Participants were 50 age-matched controls without HF and 100 outpatients with HF and reduced left ventricular function. In outpatients with HF and controls (6% each), no significant difference was found in TD prevalence. Findings revealed no link between heart function, thiamin intake, use, or dose of diuretics and TD. They found that erythrocyte thiamin pyrophosphate (TPP) and F2-isoprostane levels were positively correlated but such a positive link was not seen between erythrocyte TPP and norepinephrine and N-terminal pro-brain natriuretic peptide. The observed low prevalence of TD in ambulatory HF participants indicated there may be a low risk for TD in ambulatory patients, unlike hospitalized patients.