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Prevalence of pre-existing dysglycaemia among inpatients with acute coronary syndrome and associations with outcomes

Diabetes Research and Clinical Practice Jul 12, 2019

Mahendran DC, et al. - In this prospective observational cohort study, researchers tested the premise that dysglycemia (including that in the pre-diabetes range) affects most patients admitted with the acute coronary syndrome (ACS) and correlates with worse outcomes. For this investigation, consecutive inpatients (aged ≥54 years) with ACS were tested and characterized into diabetes (prior diagnosis/ HbA1c ≥6.5%, ≥48mmol/mol), pre-diabetes (HbA1c 5.7-6.4%, 39-47mmol/mol) and no diabetes (HbA1c ≤5.6%, ≤38mmol/mol) groups. According to results, 847 consecutive inpatients presented with ACS over 2 years. Findings revealed that nearly half of the dysglycemic patients were pre-diabetic. A higher odds of acute pulmonary edema and acute coronary syndrome recurrence was seen in inpatients with diabetes. Routine HbA1c testing is justified to identify people who may benefit from anti-hyperglycemic cardioprotective agents and alteration of lifestyle to avoid pre-diabetes progression due to the elevated incidence of dysglycemia and association with poorer clinical results.

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