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Prevalence of onchocerciasis and associated clinical manifestations in selected hypoendemic communities in Ghana following long-term administration of ivermectin

BMC Infectious Diseases May 24, 2019

Otabil KB, et al. - The prevalence of onchocerciasis as well as the clinical conditions frequently related with the disease were assessed in three endemic communities (Tanfiano, Senya and Kokompe) in Ghana which have seen 18 to 20 rounds of mass drug administration of ivermectin. In this cross-sectional study, researchers randomly examined the population and selected 114 participants based on the eligibility criteria. The Tanfiano, Senya, Kokompe communities had microfilaria prevalence of 13.2%, 2.4%, and 2.9%, with nodule prevalence of 5.3%, 4.9% and 14.3%, respectively. The participants most frequently presented with dermatitis (25.4%), then both visual impairment and nodules (7.9% each) and then blindness (4.4%). Findings showed the persistence of infection with onchocerciasis and the commonly associated clinical manifestations of the disease in the study communities despite several years of mass drug administration with ivermectin.

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