Prevalence of impaired renal function in virologically suppressed people living with HIV compared with controls: The Copenhagen Comorbidity in HIV Infection (COCOMO) study
HIV Medicine Oct 16, 2019
Petersen N, Knudsen AD, Mocroft A, et al. - Researchers sought to assess the prevalence of renal impairment among Caucasian people living with HIV (PLWH) who were virologically suppressed on antiretroviral treatment and did not have injecting drug use or hepatitis C from the COCOMO study. Renal impairment was defined as one measurement of estimated glomerular filtration rate ≤ 60 mL/min/1.73 m2, and associated factors were assessed using adjusted logistic regression models. A subanalysis was done to determine the impact of HIV-related factors. Among 598 PLWH and 2598 controls, renal impairment was prevalent in 3.7% and 1.7%, respectively. Thus low-risk virologically suppressed Caucasian PLWH had a low prevalence of renal impairment; however, relative to controls, this prevalence is significantly higher. After adjustment, renal impairment was observed in independent association with HIV status. In addition, renal impairment was strongly correlated with older age, female gender and diabetes. The strength of this association between HIV status and renal impairment heightened with older age. Hence, renal impairment remains a concern in all PLWH and needs ongoing attention.
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