Mannik LA, et al. - Researchers determined the characteristics of cystic fibrosis (CF) patients with hypoglycemia during the oral glucose tolerance test (OGTT), as well as, the incidence and time to development of CF-related diabetes (CFRD) in those with hypoglycemia. In this cohort study of CF adults at the Toronto Adult CF Clinic, patients were divided as follows based on their plasma glucose (PG) level 2 h after a 75 g OGTT: hypoglycemia (PG ≤ 3.9 mmol/L) or no hypoglycemia (PG > 3.9 mmol/L). Using Fisher's exact test or Mann-Whitney-Wilcoxon test, differences between groups were evaluated. Patients with CF were commonly detected having hypoglycemia following OGTT, however, these patients had low 10 year risk of developing CFRD. A higher risk for hypoglycemia was seen among males and those who were heterozygous deltaF508.