Matsue Y, Kamiya K, Saito H, et al. - Researchers performed a prospective multicenter cohort study, the FRAGILE‐HF study, to determine the prevalence, overlap, as well as the prognostic implications of physical and social frailties and cognitive dysfunction among hospitalized elderly patients (aged ≥ 65 years) experiencing heart failure. Employing the Fried phenotype model, Makizako’s 5 items, and Mini‐Cog, they assessed physical frailty, social frailty, and cognitive dysfunction, respectively. The combined endpoint of heart failure rehospitalization and all‐cause mortality within 1 year was the primary study outcome. Overall 1,180 hospitalized patients (median age, 81 years; 57.4% male) were enrolled. Of those, 56.1%, 66.4%, and 37.1% had physical frailty, social frailty, and cognitive dysfunction, respectively. The occurrence of the combined endpoint in 383 patients was noted during the follow‐up. Among participants, the coexistence of multiple frailty domains was prevalent. Experts noted that holistic evaluation of multi‐domain frailty afforded additive worth to recognized prognostic factors.