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Prevalence and prognostic impact of the coexistence of multiple frailty domains in elderly patients with heart failure: The FRAGILE‐HF cohort study

European Journal of Heart Failure Jul 17, 2020

Matsue Y, Kamiya K, Saito H, et al. - Researchers investigated prevalence, overlap, as well as prognostic implications of physical and social frailties and cognitive dysfunction among hospitalized elderly (aged ≥ 65 years) patients experiencing heart failure, in a prospective multicentre cohort study named the FRAGILE‐HF study. The combined endpoint of heart failure rehospitalization and all‐cause mortality within 1 year was the primary study outcome. The occurrence of the combined endpoint was reported in 383 patients during follow‐up. A 22.0% net reclassification improvement for the primary outcome was achieved by including the number of frailty domains into the pre‐existing risk model. Overall, in this study sample, the coexistence of multiple frailty domains was prevalent. It was also noted that holistic evaluation of multi‐domain frailty offered additive value to familiar prognostic factors.

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