de Apodaca MJFR, et al. - Among 1,401 people living with HIV (PLHIV) in Spain, researchers investigated the prevalence and patterns of drug use by performing an observational cross-sectional study. They identified this study as the largest multi-center cross-sectional study on this topic. Using an online computer-assisted self-administered interview, they gathered data via 33 sites across Spain. Substances that were most frequently consumed included alcohol (86.7%), tobacco (55.0%), illicit drugs (49.5%), and other substances (27.1%). Cannabis (73.8%), cocaine powder (53.9%), and poppers (45.4%) were the most prevalent illicit drugs used. Although heterosexuals who used heroin and cocaine had the most problems with adherence to HIV treatment and had the worst health status, men who have sex with men showed the highest prevalence of drug use.