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Prevalence and incidence of intraventricular conduction delays and outcomes in patients with heart failure and reduced ejection fraction: Insights from PARADIGM‐HF and ATMOSPHERE

European Journal of Heart Failure Jul 31, 2020

Kristensen SL, Castagno D, Shen L, et al. - In the PARADIGM‐HF and ATMOSPHERE trials, researchers investigated the importance of intraventricular conduction delay (IVCD), incidence of new IVCD and its correlation with outcomes in heart failure and reduced ejection fraction (HFrEF). Among 11,861 patients without an intracardiac device, 1,789 (15.1%) patients had left bundle branch block (LBBB), 524 (4.4%) RBBB, 454 (3.8%) non‐specific IVCD, 2,588 (21.8%) “mildly abnormal” QRS (110‐129 milliseconds [ms]) and 6,506 (54.9%) QRS < 110 ms, at baseline. Patients with HFrEF exhibited worse clinical outcomes in correlation with a wide QRS irrespective of morphology. Findings revealed annual incidence of nearly 2.5% for new‐onset LBBB, and its association with a higher risk of adverse outcomes, emphasizing the value of repeat ECG review.

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