Prevalence and incidence of intra‐ventricular conduction delays and outcomes in patients with heart failure and reduced ejection fraction: Insights from PARADIGM‐HF and ATMOSPHERE
European Journal of Heart Failure Feb 14, 2021
Kristensen SL, Castagno D, Shen L, et al. - In the PARADIGM‐HF (Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial) and ATMOSPHERE (Aliskiren Trial to Minimize OutcomeS in Patients with HEart FailuRE) trials, researchers examined the importance of intra‐ventricular conduction delay (IVCD), the incidence of new IVCD as well as its link with results in heart failure and reduced ejection fraction (HFrEF). Among 11,861 patients without an intracardiac device, experts estimated the risk of the primary composite outcome of cardiovascular death or heart failure hospitalization and all‐cause death by applying Cox regression based on baseline QRS duration and morphology. Findings revealed that worse clinical outcomes were observed in relation to a wide QRS, regardless of morphology, in patients suffering from HFrEF. The annual incidence of new‐onset left bundle branch block was estimated to be around 2.5%, and related to a higher risk of adverse results, this emphasizes the importance of repeat electrocardiogram review.
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