Rheude T, Pellegrini C, Lessmann L, et al. - Among 495 patients who underwent transfemoral transcatheter aortic valve implantation (TAVI) for severe symptomatic aortic stenosis, researchers investigated the prevalence and clinical influence of iron deficiency (ID). A composite of all-cause death, unplanned readmission for worsening heart failure or red blood cell transfusions during the first year post-TAVI was assessed as the primary endpoint. The occurrence of the primary endpoint was reported in 22% (109/495) of the study population. Findings revealed a common prevalence of ID in TAVI patients (54%). The presence of ID was related to adverse clinical outcome post-TAVI. In contemporary TAVI patients, administering intravenous iron for iron deficiency correction seemed feasible. It remained unknown if this attenuates transfusion rates and influences clinical result post-TAVI.